Publications
2020
Ventricular restitution predicts paroxysmal atrial fibrillation in horses
J. Ramírez and A. Tinker
Function 2020; 2(1): zqaa038.
Contribution: compiling information, drafting and editing the manuscript and Figure.
2019
Resting heart rate and type 2 diabetes – a complex relationship in need of greater understanding
P. B. Munroe, J. Ramírez and S. van Duijvenboden
Journal of the American College of Cardiology 2019; 74(17)
Contribution: compiling information, drafting and editing the manuscript.
Neurys Gómez; Julia Ramírez; Juan Pablo Martínez; Pablo Laguna
IEEE Journal of Biomedical and Health Informatics (In Press)
Integration of genetic-fine mapping and multi-omics data reveals candidate effector genes for hypertension
S. van Duijvenboden, J. Ramírez, W. J. Young, K. J. Olczak, F. Ahmed, M. J. A. Y. Alhammadi, ICBP, C. G. Bell, A. P. Morris and P. B. Munroe.
American Journal of Human Genetics (In Press)
Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Nay Aung, Lin Wang, C Anwar A Chahal, Karim Lekadir, Steffen E Petersen, Patricia B Munroe
European Heart Journal – Digital Health 4(4):316-324
William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, (…), Julia Ramírez, (…), Pier D. Lambiase, Larisa G. Tereshchenko & Patricia B. Munroe
Nature Communications volume 14, Article number: 1411 (2023)
2023
Michele Orini, Stefan van Duijvenboden, William J Young, Julia Ramírez, Aled R Jones, Andrew Tinker, Patricia B Munroe, Pier D Lambiase
European Heart Journal – Digital Health, ztad007
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, …, Julia Ramírez, …, Hampton L Leonard
Genome biology 23(1), 1-42, BioMed Central, 2022/12
A saturated map of common genetic variants associated with human height
Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, …, Julia Ramírez, …, Peter M. Visscher & Joel N. Hirschhorn
JOURNAL OF HUMAN HYPERTENSION 36 (SUPPL 1), 4-4, 2022
Classifying hypertension mediated left ventricular hypertrophy patterns from the electrocardiogram using machine learning
Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Lin Wang, Karim Lekadir, Steffen Petersen, Patricia Munroe
JOURNAL OF HUMAN HYPERTENSION 36 (SUPPL 1), 4-4, 2022
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong,…, Julia Ramirez, …, Christopher Newton-Cheh & Patricia B. Munroe
Nature Communications volume 13, Article number: 5144 (2022)
ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations
Julia Ramírez, Antti Kiviniemi, Stefan van Duijvenboden, Andrew Tinker, Pier D. Lambiase, Juhani Junttila, Juha S. Perkiömäki, Heikki V. Huikuri, Michele Orini and Patricia B. Munroe
Journal of the American Heart Association. 2022;11:e025897
ECG T-wave Morphology Variations Predict Ventricular Arrhythmic Risk in Low- and Moderate-risk Populations
J. Ramírez, A. Kiviniemi, S. van Duijvenboden, A. Tinker, P. D. Lambiase, J. Junttila, J. S. Perkiömäki, H. V. Huikuri, M. Orini, P. B. Munroe
Journal of the American Heart Association (In Press)
2022
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
S. Ramdas, J. Judd, S. E. Graham, (…), J. Ramírez, (…), C. J. Willer, X. Zhu, C. D. Brown
American Journal of Human Genetics (In Press)
2022
Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors
J. Ramírez, S. van Duijvenboden, W.J. Young, A. Tinker, P.D. Lambiase, M. Orini, P.B. Munroe
Circulation – Genomics and Precision Medicine (In Press)
2022
Weighted Time Warping Improves T-wave Morphology Markers Clinical Significance
F. Palmieri, P. Gomis, D. Ferreira, E. Pueyo, J. P. Martínez, P. Laguna and J. Ramírez
IEEE Transactions on Biomedical Engineering (In Press), doi: 10.1109/TBME.2022.3153791.
The power of genetically diverse individuals in genome-wide association studies of blood lipid levels
S.E. Graham, S.L. Clarke, K.H.Wu, (…), J. Ramírez, (…), P. Deloukas, Y.V. Sun and C.J. Willer
Nature 600, 675-679
2021
Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders
S. van Duijvenboden*, J. Ramírez*, W. Young, M. Orini, B. Mifsud, A. Tinker, P. Lambiase, P. B. Munroe
Human Molecular Genetics, ddab197
2021
Analysing electrocardiographic traits and predicting cardiac risk in UK Biobank
J. Ramírez, S. van Duijvenboden, W.J. Young, M. Orini, A. Jones, P. Lambiase, P. Munroe, A. Tinker
JRSM Cardiovascular Disease, January 2021
2021
ECG-based Monitoring of Blood Potassium Concentration: Periodic versus Principal Component as Lead Transformation for Biomarker Robustness
F. Palmieri, P. Gomis, D. Ferreira, A. Martín-Yebra, Esther Pueyo, J. P. Martínez, J. Ramírez, P. Laguna
Biomedical Signal Processing and Control 2021, 68: 102719
2021
A novel two-stage heart arrhythmia ensemble classifier
M.J. Rezaei, J.R. Woodward, J. Ramírez, P.B. Munroe
Computers 2021, 10(5), 60
2021
Genetically-Determined Serum Calcium levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank
WJ Young, HR Warren, DO Mook-Kanamori, J Ramírez, S van Duijvenboden, M Orini, A Tinker, D van Heemst, PD Lambiase, JW Jukema, PB Munroe, R Noordam
Circulation Genomics and Precision Medicine 2021; 14(3):e003231
2021
Nonlinear T-wave Time Warping-based Sensing Model for Non-invasive Personalized Blood Potassium Monitoring in Hemodialysis Patients
F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna
Sensors 2021, 21(8), 2710.
2021
Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics
F. Palmieri, P. Gomis, J. Ruiz, B. Bergasa, D. Ferreira, A. Martín-Yebra, H. Ahmed, J. P. Martínez, E. Pueyo, J. Ramírez, P. Laguna
Scientific Reports 11, 3883.
2021
No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: a Mendelian Randomization Analysis
J. Mensah-Kane, A. F. Schmidt, A. D. Hingorani, C. Finan, Y. Chen, S. van Duijvenboden, M. Orini, P. D. Lambiase, A. Tinker, E. Marouli, P. B. Munroe* and J. Ramírez*
Frontiers in Genetics 12(59)
2021
Characterization of T wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate
H. Ahmed, F. Palmieri, J. Ramírez, P. Laguna, J. Ruiz, D. Ferreira, M. Potse, C. Sanchez-Tapia, E. Pueyo
IEEE Transactions on Biomedical Engineering 68(8), 2467-2478
A method to minimise the impact of ECG marker inaccuracies on the spatial QRS-T angle: Evaluation on 1,512 manually annotated ECGs
W. J. Young, S. van Duijvenboden, J. Ramírez, A. Jones, A. Tinker, P. B. Munroe, P. D. Lambiase, M. Orini
Biomedical Signal Processing and Control 64, 102305
2020
The effects of polygenic risk for psychiatric disorders and smoking behavior on psychotic experiences in UK Biobank
J. García-González, J. Ramírez, D. M. Howard, C. H. Brennan, P. B. Munroe, R. Keers
Translational Psychiatry 2020; 10(330)
Contribution: Supervision and editing the manuscript.
2020
Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation
L. C. Weng, A. Hall, S. H. Choi, (…), J. Ramírez, (…), K. Lunetta, P. Ellinor, and S. Lubitz.
Circulation: Genomic and Precision Medicine 2020; 13:387-395
Contribution: Individual study analyst and data contributor for the meta-analysis.
2020
Genetic Basis and Prognostic Value of Exercise QT Dynamics
S. van Duijvenboden*, J. Ramírez*, W. J. Young, B. Mifsud, M. Orini, A. Tinker, P. B. Munroe and P. D. Lambiase
Circulation: Genomic and Precision Medicine 2020; 13(4)
Contribution: Second leading author, data analysis, manuscript drafting and editing.
2020
Common Genetic Variants Modulate the Electrocardiographic T-peak-to-end Interval
J. Ramírez*, S. van Duijvenboden*, W. J. Young, M. Orini, P. Lambiase, P. B. Munroe, A. Tinker
American Journal of Human Genetics 2020; 106(6):764-778
Contribution: First leading author, data analysis, manuscript drafting and editing.
2020
Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction
Ntalla, L. C. Weng, J. Cartwright, (…), J. Ramírez, (…), Y. Jamshidi , S. Lubitz and P. B. Munroe
Nature Communications 2020; 11(1):1-12
Contribution: Individual study analyst and data contributor for the meta-analysis.
Cardiovascular predictive value and genetic basis of ventricular repolarization dynamics
J. Ramírez, S. van Duijvenboden, N. Aung, P. Laguna, E. Pueyo, A. Tinker, P. D. Lambiase, M. Orini and P.B. Munroe
Circulation: Arrhythmia and Electrophysiology 2019; 12:e007549
Contribution: Leading author, data analysis, manuscript drafting and editing.
2019
Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants
K. Fung, J. Ramírez, H. R. Warren, N. Aung, A. M. Lee, E. Tzanis, S. E. Petersen and P. B. Munroe
Scientific Reports 2019; 9:9143
Contribution: Supervision and editing the manuscript.
2019
The effects of polygenic risk for psychiatric disorders and smoking behavior on psychotic experiences in UK Biobank
J. García-González, J. Ramírez, D. M. Howard, C. H. Brennan, P. B. Munroe, R. Keers
Translational Psychiatry 2020; 10(330)
Contribution: Supervision and editing the manuscript.
Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6
B. P. Prins, T. J. Mead, J. A. Brody, (…), J. Ramirez, (…), P. B Munroe, D. E Arking, C. W Lo, Y. Jamshidi
Genome Biology 2018; 19(1):87
Contribution: Individual study analyst and data contributor for the meta-analysis.
2018
Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system
J. Ramírez*, S. van Duijvenboden*, I. Ntalla*, B. Mifsud, H. R. Warren, E. Tzanis, M. Orini, A. Tinker, P. D. Lambiase and P. B. Munroe
Nature Communications 2018; 9(1):1947
Contribution: First leading author, data analysis, manuscript drafting and editing.
Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model
J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayes de Luna, J. P. Martinez, P Laguna and E. Pueyo
PLoS ONE 2017; 12(10):e0186152.
Contribution: Leading author, data analysis, manuscript drafting and editing.
2017
T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure
J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayes de Luna, J. P. Martinez, E. Pueyo and P. Laguna
JAHA 2017; 6(5):e005310.
Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves
J. Ramírez, M. Orini, J. D. Tucker, Esther Pueyo and Pablo Laguna.
IEEE Trans on Biomed Eng, 64(7), pp. 1619-1630.
Contribution: First leading author, data analysis, manuscript drafting and editing.
Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers
J. Ramírez, V. Monasterio, A. Mincholé, M. Llamedo, G. Lenis, I Cygankiewicz, A. Bayes de Luna, M. Malik, J. P. Martinez, P Laguna and E. Pueyo
J Electrocardiol 48, pp. 551-557.
Contribution: First leading author, data analysis, manuscript drafting and editing.
QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death
J. Ramírez, P. Laguna, A. Bayés de Luna, M. Malik and E. Pueyo
J Electrocardiol 47, pp. 842-848.
Contribution: First leading author, data analysis, manuscript drafting and editing.
Classifying Left Ventricular Hypertrophy from Extracted Morphological Electrocardiogram Biomarkers using Random Forest
Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Lin Wang, Karim Lekadir, Steffen E Petersen, Patricia B Munroe
CINC 2022
Combination of Isolation Forest, SMOTE and Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia
Mercedeh J. Rezaei; John R. Woodward; Julia Ramirez; Patricia Munroe
International Conference on Biomedical Innovations and Applications.
Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia
M. J. Rezaei, J. Woodward, J. Ramírez, P.B. Munroe.
International Conference on Biomedical Innovations and Applications.
Weighted Time Warping T-wave Analysis Robust to Delineation Errors: Clinical Implications
F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez
Computing in Cardiology. Brno (Czech Republic)
2021
«Time-Warping» ponderado sobre la onda T para Reducir el Impacto de Errores de Delineación: Implicaciones Clínicas
F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez
Congreso Annual de la Sociedad Española de Ingeniería Biomédica.
Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate
S. van Duijvenboden, J. Ramírez, W.J. Young, A. Tinker, P.B. Munroe, P.D. Lambiase, M. Orini
Computing in Cardiology. Rimini (Italy)
2020
Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?
W.J. Young, J. Ramírez, S. van Duijvenboden, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini
Computing in Cardiology. Rimini (Italy)
2020
Potassium Monitoring From Multilead T-wave Morphology Changes During Hemodyalisis: Periodic Versus Principal Component Analysis
F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, P. Laguna, J.P. Martínez, J. Ramírez
Computing in Cardiology. Rimini (Italy)
2020
Sex Differences in the Morphology of RR-Matched T-waves
J. Ramírez, S. van Duijvenboden, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini
Computing in Cardiology. Rimini (Italy)
2020
Interaction Between ECG and Genetic Markers of Coronary Artery Disease
J. Ramírez, S. van Duijvenboden, W.J. Young, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini
Computing in Cardiology. Rimini (Italy)
2020
Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes
N. Aung, W.J. Young, S. van Duijvenboden, J. Ramírez, S.E. Petersen, P.B. Munroe
Computing in Cardiology. Rimini (Italy)
2020
Data augmentation for heart arrhythmia classification
M. Jafarkhanloo Rezaei, J. Woodward, J. Ramírez, P. B. Munroe
IEEE International Conference on Tools with Artificial Intelligence (ICTAI)
2020
Monitorización en diálisis de la Concentración de Potasio en Sangre mediante los cambios en la morfología multi-lead de la onda T: Comparación Entre usar la transformación en Componentes Periódicas y Principales
Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martin, Esther Pueyo, Pablo Laguna, Juan Pablo Martínez and Julia Ramírez
XL Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Bilbao, Spain
Transmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Serum Potassium Levels
Syed Hassaan Ahmed Bukhari, Flavio Palmieri, Dina Ferreira, Mark Potse, Julia Ramírez, Pablo Laguna, Carlos Sanchez and Esther Pueyo
Computing in Cardiology. Singapore, Singapore
2019
T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients
Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Beatriz Bergasa, Ferreira Dina, Alba Martin, Syed Hassaan Ahamed, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez and Pablo Laguna
Computing in Cardiology. Singapore, Singapore
Winner of the “ESC-CinC Clinical Needs Translational Award”
Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology
J. Ramírez, S. van Duijvenboden, P. Laguna, E. Pueyo, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini.
Computing in Cardiology. Maastrich, The Netherlands.
Winner of the “ESC-CinC Clinical Needs Translational Award”.
2018
T-wave Morphology Restitution in Chronic Heart Failure Patients with Atrial Fibrillation,
F. Palmieri, J.P. Martínez, L. Burattini, J. Ramírez.
Computing in Cardiology. Maastrich, The Netherlands.
Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure
J. Ramirez, M. Orini, E. Pueyo, P. Laguna.
Computing in Cardiology. Rennes, France.
2017
T-wave Morphology Restitution Dependency with Heart Rate Range and Its Association with Sudden Cardiac Death in Chronic Heart Failure
J. Ramirez, M. Orini, E. Pueyo, P. Laguna.
Computing in Cardiology. Rennes, France.
2017
Quantification of T-wave Morphological Variability Using Time-Warping Methods,
J. Ramirez, M. Orini, E. Pueyo, P. Laguna.
European Medical and Biological Engineering and Nordic-Baltic Biomedical Engineering conference. Tampere, Finland.
Cuantificación de la variabilidad de la amplitud de la onda T mediante técnicas de re-parametrización temporal
J. Ramírez, M. Orini, J.D. Tucker, et.al.,
XXXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Valencia, Spain.
2016
An index for T-wave pointwise amplitude variability quantification.
J. Ramírez, M. Orini, J. D. Tucker, Esther Pueyo and Pablo Laguna.
Computing in Cardiology. Vancouver, Canada,
Winner of the “Mortara” mobility fellowship.
2016
Post extrasystolic T wave change to stratify risk of pump failure death in patients with chronic heart failure.
G. Lenis, R. Menges, J. Ramírez, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, P. Laguna, O. Dossel,
Computing in Cardiology. Vancouver, Canada, 2016,
Winner of the “Mortara” mobility fellowship.
Modulación circadiana y de género de las relaciones QT/RR y T-pico-a-fin/RR en pacientes con insuficiencia cardiaca
J. Ramírez, P. Laguna y E. Pueyo ,
XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Barcelona, Spain.
2014
Circadian pattern and sex differences of QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure patients
J. Ramírez, I. Cygankiewicz, P. Laguna, M. Malik, E. Pueyo,
Computing in Cardiology, Cambridge, MA, United States of America.
Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion
J. Ramírez, A. Mincholé, J. Bolea, P. Laguna, E. Pueyo,
Computing in Cardiology. Zaragoza, Spain,
Winner of the Young Investigator Award for the best written and oral presentation.
Caracterización de la respuesta de la repolarización a cambios en el ritmo cardiaco provocados por una prueba de Tilt
J. Ramírez, A. Mincholé, P. laguna, et al,
XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). San Sebastián, Spain.
2012
Characterization of cardiac repolarization response to heart rate changes provoked by a Tilt test
J. Ramírez, A. Mincholé, P. Laguna, E. Pueyo
Computing in Cardiology. Krakow, Poland,
Winner of the “Bill and Sanders Award” for the best poster presentation.