Publications

Our work

Editorial Publications

2020

Ventricular restitution predicts paroxysmal atrial fibrillation in horses

J. Ramírez and A. Tinker

Function 2020; 2(1): zqaa038.

Contribution: compiling information, drafting and editing the manuscript and Figure.

2019

Resting heart rate and type 2 diabetes – a complex relationship in need of greater understanding

P. B. Munroe, J. Ramírez and S. van Duijvenboden

Journal of the American College of Cardiology 2019; 74(17)

Contribution: compiling information, drafting and editing the manuscript.

Journal Publications

2022

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, …, Julia Ramírez, …, Hampton L Leonard

Genome biology 23(1), 1-‌42, BioMed Central, 2022/‌12

2022

A saturated map of common genetic variants associated with human height

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, …, Julia Ramírez, …, Peter M. Visscher & Joel N. Hirschhorn

JOURNAL OF HUMAN HYPERTENSION 36 (SUPPL 1), 4-‌4, 2022

2022

Classifying hypertension mediated left ventricular hypertrophy patterns from the electrocardiogram using machine learning

Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Lin Wang, Karim Lekadir, Steffen Petersen, Patricia Munroe

JOURNAL OF HUMAN HYPERTENSION 36 (SUPPL 1), 4-‌4, 2022

2022

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong,…, Julia Ramirez, …, Christopher Newton-Cheh & Patricia B. Munroe

Nature Communications volume 13, Article number: 5144 (2022)

2022

ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations

Julia Ramírez, Antti Kiviniemi, Stefan van Duijvenboden, Andrew Tinker, Pier D. Lambiase, Juhani Junttila, Juha S. Perkiömäki, Heikki V. Huikuri, Michele Orini and Patricia B. Munroe

Journal of the American Heart Association. 2022;11:e025897

2022

ECG T-wave Morphology Variations Predict Ventricular Arrhythmic Risk in Low- and Moderate-risk Populations

J. Ramírez, A. Kiviniemi, S. van Duijvenboden, A. Tinker, P. D. Lambiase, J. Junttila, J. S. Perkiömäki, H. V. Huikuri, M. Orini, P. B. Munroe

Journal of the American Heart Association (In Press)

2022

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

S. Ramdas, J. Judd, S. E. Graham, (…), J. Ramírez, (…), C. J. Willer, X. Zhu, C. D. Brown

American Journal of Human Genetics (In Press)

2022

Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors

J. Ramírez, S. van Duijvenboden, W.J. Young, A. Tinker, P.D. Lambiase, M. Orini, P.B. Munroe

Circulation – Genomics and Precision Medicine (In Press)

2022

Weighted Time Warping Improves T-wave Morphology Markers Clinical Significance

F. Palmieri, P. Gomis, D. Ferreira, E. Pueyo, J. P. Martínez, P. Laguna and J. Ramírez

IEEE Transactions on Biomedical Engineering (In Press), doi: 10.1109/TBME.2022.3153791.

2021

The power of genetically diverse individuals in genome-wide association studies of blood lipid levels

S.E. Graham, S.L. Clarke, K.H.Wu, (…), J. Ramírez, (…), P. Deloukas, Y.V. Sun and C.J. Willer

Nature 600, 675-679

2021

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders

S. van Duijvenboden*, J. Ramírez*, W. Young, M. Orini, B. Mifsud, A. Tinker, P. Lambiase, P. B. Munroe

Human Molecular Genetics, ddab197

2021

Analysing electrocardiographic traits and predicting cardiac risk in UK Biobank

J. Ramírez, S. van Duijvenboden, W.J. Young, M. Orini, A. Jones, P. Lambiase, P. Munroe, A. Tinker

JRSM Cardiovascular Disease, January 2021

2021

ECG-based Monitoring of Blood Potassium Concentration: Periodic versus Principal Component as Lead Transformation for Biomarker Robustness

F. Palmieri, P. Gomis, D. Ferreira, A. Martín-Yebra, Esther Pueyo, J. P. Martínez, J. Ramírez, P. Laguna

Biomedical Signal Processing and Control 2021, 68: 102719

2021

A novel two-stage heart arrhythmia ensemble classifier

M.J. Rezaei, J.R. Woodward, J. Ramírez, P.B. Munroe

Computers 2021, 10(5), 60

2021

Genetically-Determined Serum Calcium levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank

WJ Young, HR Warren, DO Mook-Kanamori, J Ramírez, S van Duijvenboden, M Orini, A Tinker, D van Heemst, PD Lambiase, JW Jukema, PB Munroe, R Noordam

Circulation Genomics and Precision Medicine 2021; 14(3):e003231

2021

Nonlinear T-wave Time Warping-based Sensing Model for Non-invasive Personalized Blood Potassium Monitoring in Hemodialysis Patients

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna

Sensors 2021, 21(8), 2710.

2021

Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics

F. Palmieri, P. Gomis, J. Ruiz, B. Bergasa, D. Ferreira, A. Martín-Yebra, H. Ahmed, J. P. Martínez, E. Pueyo, J. Ramírez, P. Laguna

Scientific Reports 11, 3883.

2021

No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: a Mendelian Randomization Analysis

J. Mensah-Kane, A. F. Schmidt, A. D. Hingorani, C. Finan, Y. Chen, S. van Duijvenboden, M. Orini, P. D. Lambiase, A. Tinker, E. Marouli, P. B. Munroe* and J. Ramírez*

Frontiers in Genetics 12(59)

2021

Characterization of T wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate

H. Ahmed, F. Palmieri, J. Ramírez, P. Laguna, J. Ruiz, D. Ferreira, M. Potse, C. Sanchez-Tapia, E. Pueyo

IEEE Transactions on Biomedical Engineering 68(8), 2467-2478

2020

A method to minimise the impact of ECG marker inaccuracies on the spatial QRS-T angle: Evaluation on 1,512 manually annotated ECGs

W. J. Young, S. van Duijvenboden, J. Ramírez, A. Jones, A. Tinker, P. B. Munroe, P. D. Lambiase, M. Orini

Biomedical Signal Processing and Control 64, 102305

2020

The effects of polygenic risk for psychiatric disorders and smoking behavior on psychotic experiences in UK Biobank

J. García-González, J. Ramírez, D. M. Howard, C. H. Brennan, P. B. Munroe, R. Keers

Translational Psychiatry 2020; 10(330)

Contribution: Supervision and editing the manuscript.

2020

Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation

L. C. Weng, A. Hall, S. H. Choi, (…), J. Ramírez, (…), K. Lunetta, P. Ellinor, and S. Lubitz.

Circulation: Genomic and Precision Medicine 2020; 13:387-395

Contribution: Individual study analyst and data contributor for the meta-analysis.

2020

Genetic Basis and Prognostic Value of Exercise QT Dynamics

S. van Duijvenboden*, J. Ramírez*, W. J. Young, B. Mifsud, M. Orini, A. Tinker, P. B. Munroe and P. D. Lambiase

Circulation: Genomic and Precision Medicine 2020; 13(4)

Contribution: Second leading author, data analysis, manuscript drafting and editing.

2020

Common Genetic Variants Modulate the Electrocardiographic T-peak-to-end Interval

J. Ramírez*, S. van Duijvenboden*, W. J. Young, M. Orini, P. Lambiase, P. B. Munroe, A. Tinker

American Journal of Human Genetics 2020; 106(6):764-778

Contribution: First leading author, data analysis, manuscript drafting and editing.

2020

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Ntalla, L. C. Weng, J. Cartwright, (…), J. Ramírez, (…), Y. Jamshidi , S. Lubitz and P. B. Munroe

Nature Communications 2020; 11(1):1-12

Contribution: Individual study analyst and data contributor for the meta-analysis.

2019

Cardiovascular predictive value and genetic basis of ventricular repolarization dynamics

J. Ramírez, S. van Duijvenboden, N. Aung, P. Laguna, E. Pueyo, A. Tinker, P. D. Lambiase, M. Orini and P.B. Munroe

Circulation: Arrhythmia and Electrophysiology 2019; 12:e007549

Contribution: Leading author, data analysis, manuscript drafting and editing.

2019

Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants

K. Fung, J. Ramírez, H. R. Warren, N. Aung, A. M. Lee, E. Tzanis, S. E. Petersen and P. B. Munroe

Scientific Reports 2019; 9:9143

Contribution: Supervision and editing the manuscript.

2019

The effects of polygenic risk for psychiatric disorders and smoking behavior on psychotic experiences in UK Biobank

J. García-González, J. Ramírez, D. M. Howard, C. H. Brennan, P. B. Munroe, R. Keers

Translational Psychiatry 2020; 10(330)

Contribution: Supervision and editing the manuscript.

2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

B. P. Prins, T. J. Mead, J. A. Brody, (…), J. Ramirez, (…), P. B Munroe, D. E Arking, C. W Lo, Y. Jamshidi

Genome Biology 2018; 19(1):87

Contribution: Individual study analyst and data contributor for the meta-analysis.

2018

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

J. Ramírez*, S. van Duijvenboden*, I. Ntalla*, B. Mifsud, H. R. Warren, E. Tzanis, M. Orini, A. Tinker, P. D. Lambiase and P. B. Munroe

Nature Communications 2018; 9(1):1947

Contribution: First leading author, data analysis, manuscript drafting and editing.

2017

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model

J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayes de Luna, J. P. Martinez, P Laguna and E. Pueyo

PLoS ONE 2017; 12(10):e0186152.

Contribution: Leading author, data analysis, manuscript drafting and editing.

2017

T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure

J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayes de Luna, J. P. Martinez, E. Pueyo and P. Laguna

JAHA 2017; 6(5):e005310.

2016

Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves

J. Ramírez, M. Orini, J. D. Tucker, Esther Pueyo and Pablo Laguna.

IEEE Trans on Biomed Eng, 64(7), pp. 1619-1630.

Contribution: First leading author, data analysis, manuscript drafting and editing.

2015

Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers

J. Ramírez, V. Monasterio, A. Mincholé, M. Llamedo, G. Lenis, I Cygankiewicz, A. Bayes de Luna, M. Malik, J. P. Martinez, P Laguna and E. Pueyo

J Electrocardiol 48, pp. 551-557.

Contribution: First leading author, data analysis, manuscript drafting and editing.

2014

QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death

J. Ramírez, P. Laguna, A. Bayés de Luna, M. Malik and E. Pueyo

J Electrocardiol 47, pp. 842-848.

Contribution: First leading author, data analysis, manuscript drafting and editing.

Peer-reviewed Conference Publications

2022

Classifying Left Ventricular Hypertrophy from Extracted Morphological Electrocardiogram Biomarkers using Random Forest

Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Lin Wang, Karim Lekadir, Steffen E Petersen, Patricia B Munroe

CINC 2022

2022

Combination of Isolation Forest, SMOTE and Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia

Mercedeh J. Rezaei; John R. Woodward; Julia Ramirez; Patricia Munroe

International Conference on Biomedical Innovations and Applications.

2022

Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia

M. J. Rezaei, J. Woodward, J. Ramírez, P.B. Munroe.

International Conference on Biomedical Innovations and Applications.

2021

Weighted Time Warping T-wave Analysis Robust to Delineation Errors: Clinical Implications

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez

Computing in Cardiology. Brno (Czech Republic)

2021

«Time-Warping» ponderado sobre la onda T para Reducir el Impacto de Errores de Delineación: Implicaciones Clínicas

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez

Congreso Annual de la Sociedad Española de Ingeniería Biomédica.

2020

Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate

S. van Duijvenboden, J. Ramírez, W.J. Young, A. Tinker, P.B. Munroe, P.D. Lambiase, M. Orini

Computing in Cardiology. Rimini (Italy)

2020

Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?

W.J. Young, J. Ramírez, S. van Duijvenboden, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini

Computing in Cardiology. Rimini (Italy)

2020

Potassium Monitoring From Multilead T-wave Morphology Changes During Hemodyalisis: Periodic Versus Principal Component Analysis

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, P. Laguna, J.P. Martínez, J. Ramírez

Computing in Cardiology. Rimini (Italy)

2020

Sex Differences in the Morphology of RR-Matched T-waves

J. Ramírez, S. van Duijvenboden, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini

Computing in Cardiology. Rimini (Italy)

2020

Interaction Between ECG and Genetic Markers of Coronary Artery Disease

J. Ramírez, S. van Duijvenboden, W.J. Young, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini

Computing in Cardiology. Rimini (Italy)

2020

Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes

N. Aung, W.J. Young, S. van Duijvenboden, J. Ramírez, S.E. Petersen, P.B. Munroe

Computing in Cardiology. Rimini (Italy)

2020

Data augmentation for heart arrhythmia classification

M. Jafarkhanloo Rezaei, J. Woodward, J. Ramírez, P. B. Munroe

IEEE International Conference on Tools with Artificial Intelligence (ICTAI)

2020

Monitorización en diálisis de la Concentración de Potasio en Sangre mediante los cambios en la morfología multi-lead de la onda T: Comparación Entre usar la transformación en Componentes Periódicas y Principales

Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martin, Esther Pueyo, Pablo Laguna, Juan Pablo Martínez and Julia Ramírez

XL Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Bilbao, Spain

2019

Transmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Serum Potassium Levels

Syed Hassaan Ahmed Bukhari, Flavio Palmieri, Dina Ferreira, Mark Potse, Julia Ramírez, Pablo Laguna, Carlos Sanchez and Esther Pueyo

Computing in Cardiology. Singapore, Singapore

2019

T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients

Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Beatriz Bergasa, Ferreira Dina, Alba Martin, Syed Hassaan Ahamed, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez and Pablo Laguna

Computing in Cardiology. Singapore, Singapore

Winner of the “ESC-CinC Clinical Needs Translational Award”

2018

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology

J. Ramírez, S. van Duijvenboden, P. Laguna, E. Pueyo, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini.

Computing in Cardiology. Maastrich, The Netherlands.

Winner of the “ESC-CinC Clinical Needs Translational Award”.

2018

T-wave Morphology Restitution in Chronic Heart Failure Patients with Atrial Fibrillation,

F. Palmieri, J.P. Martínez, L. Burattini, J. Ramírez.

Computing in Cardiology. Maastrich, The Netherlands.

2017

Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure

J. Ramirez, M. Orini, E. Pueyo, P. Laguna.

Computing in Cardiology. Rennes, France.

2017

T-wave Morphology Restitution Dependency with Heart Rate Range and Its Association with Sudden Cardiac Death in Chronic Heart Failure

J. Ramirez, M. Orini, E. Pueyo, P. Laguna.

Computing in Cardiology. Rennes, France.

2017

Quantification of T-wave Morphological Variability Using Time-Warping Methods,

J. Ramirez, M. Orini, E. Pueyo, P. Laguna.

European Medical and Biological Engineering and Nordic-Baltic Biomedical Engineering conference. Tampere, Finland.

2016

Cuantificación de la variabilidad de la amplitud de la onda T mediante técnicas de re-parametrización temporal

J. Ramírez, M. Orini, J.D. Tucker, et.al.,

XXXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Valencia, Spain.

2016

An index for T-wave pointwise amplitude variability quantification.

J. Ramírez, M. Orini, J. D. Tucker, Esther Pueyo and Pablo Laguna.

Computing in Cardiology. Vancouver, Canada,

Winner of the “Mortara” mobility fellowship.

2016

Post extrasystolic T wave change to stratify risk of pump failure death in patients with chronic heart failure.

G. Lenis, R. Menges, J. Ramírez, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, P. Laguna, O. Dossel,

Computing in Cardiology. Vancouver, Canada, 2016,

Winner of the “Mortara” mobility fellowship.

2014

Modulación circadiana y de género de las relaciones QT/RR y T-pico-a-fin/RR en pacientes con insuficiencia cardiaca

J. Ramírez, P. Laguna y E. Pueyo ,

XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Barcelona, Spain.

2014

Circadian pattern and sex differences of QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure patients

J. Ramírez, I. Cygankiewicz, P. Laguna, M. Malik, E. Pueyo,

Computing in Cardiology, Cambridge, MA, United States of America.

2013

Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion

J. Ramírez, A. Mincholé, J. Bolea, P. Laguna, E. Pueyo,

Computing in Cardiology. Zaragoza, Spain,

Winner of the Young Investigator Award for the best written and oral presentation.

2012

Caracterización de la respuesta de la repolarización a cambios en el ritmo cardiaco provocados por una prueba de Tilt

J. Ramírez, A. Mincholé, P. laguna, et al,

XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). San Sebastián, Spain.

2012

Characterization of cardiac repolarization response to heart rate changes provoked by a Tilt test

J. Ramírez, A. Mincholé, P. Laguna, E. Pueyo

Computing in Cardiology. Krakow, Poland,

Winner of the “Bill and Sanders Award” for the best poster presentation.