Journal Publications

2020

Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval

Julia Ramírez, Stefan van Duijvenboden, William J. Young, Michele Orini, Pier D. Lambiase, Patricia B. Munroe, Andrew Tinker

American Journal of Human Genetics

The effects of polygenic risk for psychiatric disorders and smoking behaviour on psychotic experiences in UK Biobank

Judit García-González, Julia Ramírez, David M Howard, Caroline H Brennan, Patricia B MunroeRobert Keers

2019

Resting Heart Rate and Type 2 Diabetes: A Complex Relationship in Need of Greater Understanding

Patricia B. MunroeJulia Ramírez and Stefan van Duijvenboden

Journal of the American College of Cardiology, Volume 74, Issue 17, October 2019.

Cardiovascular Predictive Value and Genetic Basis of Ventricular Repolarization Dynamics

Julia Ramírez, Stefan van Duijvenboden, Nay Aung, Pablo Laguna, Esther Pueyo, Andrew Tinker, Pier D. Lambiase, Michele Orini, Patricia B. Munroe

Circulation: Arrhythmia and Electrophysiology. 2019;12:e007549

Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants.

Fung, Kenneth; Ramírez, Julia; Warren, Helen R; Aung, Nay; Lee, Aaron M; Tzanis, Evan; Petersen, Steffen E; Munroe, Patricia B.

Scientific Reports, 9, Article number: 9143 (2019)

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 210 loci underlying cardiac conduction.

Ioanna Ntalla, Lu-Chen Weng, James H Cartwright, (…), Julia Ramirez, Stefan Van Duijvenboden, David O. Arnar, Daniel F. Gudbjartsson, Hilma Holm, Patrick Sulem, Gudmar Thorleifsson, Rosa Thorolfsdottir, Unnur Thorsteinsdottir, Emelia Benjamin, Andrew Tinker, Kari Stefansson, Patrick T. Ellinor, Yalda Jamshidi, Steven A. Lubitz, Patricia B. Munroe

bioRxiv

2018

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6.

Bram P Prins, Timothy J Mead, Jennifer A Brody, Gardar Sveinbjornsson, Ioanna Ntalla, Nathan A Bihlmeyer, Marten van den Berg, Jette Bork-Jensen, Stefania Cappellani, Stefan Van Duijvenboden, Nikolai T Klena, George C Gabriel, Xiaoqin Liu, Cagri Gulec, Niels Grarup, Jeffrey Haessler, Leanne M Hall, Annamaria Iorio, Aaron Isaacs, Ruifang Li-Gao, Honghuang Lin, Ching-Ti Liu, Leo-Pekka Lyytikäinen, Jonathan Marten, Hao Mei, Martina Müller-Nurasyid, Michele Orini, Sandosh Padmanabhan, Farid Radmanesh, Julia Ramirez, (…), Patricia B Munroe, Dan E Arking, Cecilia W Lo, Yalda Jamshidi.

Genome biology, 19, Article number: 87 (2018)

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system.

Ramírez, Julia; van Duijvenboden, Stefan; Ntalla, Ioanna; Mifsud, Borbala; Warren, Helen R; Tzanis, Evan; Orini, Michele; Tinker, Andrew; Lambiase, Pier D; Munroe, Patricia B.

Nature Communications, 9, Article number: 1947 (2018)

2017

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model.

Ramírez, Julia; Orini, Michele; Mincholé, Ana; Monasterio, Violeta; Cygankiewicz, Iwona; de Luna, Antonio Bayés; Martínez, Juan Pablo; Laguna, Pablo; Pueyo, Esther.

PLoS One, 12(10): e0186152.

Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves.

Ramírez, Julia; Orini, Michele; Tucker, J Derek; Pueyo, Esther; Laguna, Pablo.

IEEE Transactions on Biomedical Engineering, Volume: 64 , Issue: 7 , July 2017.

T‐Wave Morphology Restitution Predicts Sudden Cardiac Death in Patients With Chronic Heart Failure.

Ramírez, Julia; Orini, Michele; Mincholé, Ana; Monasterio, Violeta; Cygankiewicz, Iwona; Bayés de Luna, Antonio; Martínez, Juan Pablo; Pueyo, Esther; Laguna, Pablo.

Journal of the American Heart Association, 2017;6:e005310.

2015

Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers.

Ramírez, Julia; Monasterio, Violeta; Mincholé, Ana; Llamedo, Mariano; Lenis, Gustavo; Cygankiewicz, Iwona; de Luna, Antonio Bayés; Malik, Marek; Martínez, Juan Pablo; Laguna, Pablo.

Journal of electrocardiology, Volume 48, Issue 4, July–August 2015, Pages 551-557.

2014

QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death.

Ramírez, Julia; Laguna, Pablo; de Luna, Antonio Bayés; Malik, Marek; Pueyo, Esther.

Journal of electrocardiology, Volume 47, Issue 6, November–December 2014, Pages 842-848.

Conference Publications

2019

Transmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Extracellular Potassium Levels

Hassaan A Bukhari, Flavio Palmieri, Dina Ferreira, Mark Potse, Julia Ramírez, Pablo Laguna, Carlos Sánchez, Esther Pueyo.

2019 Computing in Cardiology (CiNC).

T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients

Flavio Palmieri, Pedro Gomis, Dina Ferreira, José Esteban Ruiz, Beatriz Bergasa, Alba Martín-Yebra, Hassaan A. Bukhari, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez, Pablo Laguna.

2019 Computing in Cardiology (CiNC).

The Genetic Architecture of T-wave Morphology Restitution.

Ramírez, Julia, van Duijvenboden, S., Laguna, P., Pueyo, E., Tinker, A., Lambiase, P., Orini, M., Munroe, P.,

CompBioMed Conference, London, United Kingdom.

21 The cardiovascular predictive value and genetic basis of T-wave morphology.

Ramirez, Julia; van Duijvenboden, Stefan; Tinker, Andrew; Lambiase, Pier; Orini, Michele; Munroe, Patricia B.

British Cardiovascular Society, Manchester, United Kingdom.

22 Cardiac repolarization during exercise reveals independent prognostic information for cardiovascular risk prediction.

van Duijvenboden, Stefan; Ramirez, Julia; Orini, Michele; Tinker, Andrew; Munroe, Patricia B; Lambiase, Pier.

British Cardiovascular Society, Manchester, United Kingdom.

2018

23 T-wave morphology restitution predicts arrhythmic risk in the UK biobank cohort.

Ramírez, J; van Duijvenboden, S; Orini, M; Tinker, A; Munroe, PB; Lambiase, PD.

Heart Rhythm Conference, Birmingham, United Kingdom.

2 QT interval and exercise qt dynamics from 58,852 individuals in UK biobank predict ventricular arrhythmias and heart failure.

van Duijvenboden, S; Ramírez, J; Orini, M; Tinker, A; Munroe, PB; Lambiase, PD.

Heart Rhythm Conference, Birmingham, United Kingdom.

T-Wave Morphology Restitution in Chronic Heart Failure Patient With Atrial Fibrillation.

Palmieri, Flavio; Burattini, Laura; Martínez, Juan Pablo; Ramírez, Julia.

Computing in Cardiology Conference (CinC), Maastrich, The Netherlands.

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology.

Ramírez, Julia; Van Duijvenboden, Stefan; Laguna, Pablo; Pueyo, Esther; Tinker, Andrew; Lambiase, Pier D; Munroe, Patricia B; Orini, Michele.

Computing in Cardiology Conference (CinC), Maastrich, The Netherlands.

2017

T-wave morphology restitution dependency with heart rate range and its association with sudden cardiac death in chronic heart failure.

Ramírez, Julia; Orini, Michele; Pueyo, Esther; Laguna, Pablo.

Computing in Cardiology (CinC), Rennes, France.

Quantification of T-wave Morphological Variability Using Time-warping Methods.

Ramírez, Julia; Orini, Michele; Pueyo, Esther; Laguna, Pablo.

EMBEC & NBC 2017, Tampere, Finland.

2016

Postextrasystolic T wave change to stratify risk of pump failure death in patients with chronic heart failure.

Lenis, Gustavo; Menges, Robert; Ramírez, Julia; Cygankiewicz, Iwona; de Luna, Antoni Bayés; Martínez, Juan Pablo; Laguna, Pablo; Dössel, Olaf.

Computing in Cardiology Conference (CinC), Vancouver, Canada.

An index for T-wave pointwise amplitude variability quantification.

Ramírez, Julia; Orini, Michele; Tucker, J Derek; Pueyo, Esther; Laguna, Pablo.

Computing in Cardiology Conference (CinC), Vancouver, Canada.

2014

Circadian pattern and sex differences of QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure patients.

Ramírez, Julia; Cygankiewicz, Iwona; Laguna, Pablo; Malik, Marek; Pueyo, Esther.

Computing in Cardiology Conference (CinC), Boston, USA.

2013

Sudden Cardiac Death Survival Prediction from Restitution Dispersion Analysis.

Ramírez, Julia; Mincholé, Ana; Bolea, Juan; Laguna, Pablo; Pueyo, Esther.

JORNADA DE JÓVENES INVESTIGADORES DEL I3A

Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion

J Ramírez, A Mincholé, J Bolea, P Laguna, E Pueyo

Computing in Cardiology Conference (CinC), Zaragoza, Spain.

2012

Characterization of cardiac repolarization response to heart rate changes provoked by a Tilt test.

Ramírez, Julia; Mincholé, Ana; Laguna, Pablo; Pueyo, Esther.

Computing in Cardiology Conference (CinC), Krakow, Poland.