Publications

Ventricular restitution predicts paroxysmal atrial fibrillation in horses

J. Ramírez and A. Tinker

Function 2020; 2(1): zqaa038.

Contribution: compiling information, drafting and editing the manuscript and Figure.

Resting heart rate and type 2 diabetes – a complex relationship in need of greater understanding

P. B. Munroe, J. Ramírez and S. van Duijvenboden

Journal of the American College of Cardiology 2019; 74(17)

Contribution: compiling information, drafting and editing the manuscript.

Time-Warping Analysis of the T-Wave Peak-to-End Interval to Quantify Ventricular Repolarization Dispersion During IschemiaPredicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using machine learning

Neurys Gómez; Julia Ramírez; Juan Pablo Martínez; Pablo Laguna

IEEE Journal of Biomedical and Health Informatics (In Press)

Integration of genetic-fine mapping and multi-omics data reveals candidate effector genes for hypertension

S. van Duijvenboden, J. Ramírez, W. J. Young, K. J. Olczak, F. Ahmed, M. J. A. Y. Alhammadi, ICBP, C. G. Bell, A. P. Morris and P. B. Munroe.

American Journal of Human Genetics (In Press)

Predicting left ventricular hypertrophy from the 12-lead electrocardiogram in the UK Biobank imaging study using machine learning

Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Nay Aung, Lin Wang, C Anwar A Chahal, Karim Lekadir, Steffen E Petersen, Patricia B Munroe

European Heart Journal – Digital Health 4(4):316-324

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

William J. Young, Jeffrey Haessler, Jan-Walter Benjamins, (…), Julia Ramírez, (…), Pier D. Lambiase, Larisa G. Tereshchenko & Patricia B. Munroe

Nature Communications volume 14, Article number: 1411 (2023)

Premature atrial and ventricular contractions detected on wearable-format ECGs and prediction of cardiovascular events

Michele Orini, Stefan van Duijvenboden, William J Young, Julia Ramírez, Aled R Jones, Andrew Tinker, Patricia B Munroe, Pier D Lambiase

European Heart Journal – Digital Health, ztad007

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Stavroula Kanoni, Sarah E Graham, Yuxuan Wang, …, Julia Ramírez, …, Hampton L Leonard

Genome biology 23(1), 1-‌42, BioMed Central, 2022/‌12

A saturated map of common genetic variants associated with human height

Loïc Yengo, Sailaja Vedantam, Eirini Marouli, Julia Sidorenko, …, Julia Ramírez, …, Peter M. Visscher & Joel N. Hirschhorn

JOURNAL OF HUMAN HYPERTENSION 36 (SUPPL 1), 4-‌4, 2022

Classifying hypertension mediated left ventricular hypertrophy patterns from the electrocardiogram using machine learning

Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Lin Wang, Karim Lekadir, Steffen Petersen, Patricia Munroe

JOURNAL OF HUMAN HYPERTENSION 36 (SUPPL 1), 4-‌4, 2022

Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

William J. Young, Najim Lahrouchi, Aaron Isaacs, ThuyVy Duong,…, Julia Ramirez, …, Christopher Newton-Cheh & Patricia B. Munroe

Nature Communications volume 13, Article number: 5144 (2022)

ECG T‐Wave Morphologic Variations Predict Ventricular Arrhythmic Risk in Low‐ and Moderate‐Risk Populations

Julia Ramírez, Antti Kiviniemi, Stefan van Duijvenboden, Andrew Tinker, Pier D. Lambiase, Juhani Junttila, Juha S. Perkiömäki, Heikki V. Huikuri, Michele Orini and Patricia B. Munroe

Journal of the American Heart Association. 2022;11:e025897

ECG T-wave Morphology Variations Predict Ventricular Arrhythmic Risk in Low- and Moderate-risk Populations

J. Ramírez, A. Kiviniemi, S. van Duijvenboden, A. Tinker, P. D. Lambiase, J. Junttila, J. S. Perkiömäki, H. V. Huikuri, M. Orini, P. B. Munroe

Journal of the American Heart Association (In Press)

A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids

S. Ramdas, J. Judd, S. E. Graham, (…), J. Ramírez, (…), C. J. Willer, X. Zhu, C. D. Brown

American Journal of Human Genetics (In Press)

Prediction of coronary artery disease and major adverse cardiovascular events using clinical and genetic risk scores for cardiovascular risk factors

J. Ramírez, S. van Duijvenboden, W.J. Young, A. Tinker, P.D. Lambiase, M. Orini, P.B. Munroe

Circulation – Genomics and Precision Medicine (In Press)

Weighted Time Warping Improves T-wave Morphology Markers Clinical Significance

F. Palmieri, P. Gomis, D. Ferreira, E. Pueyo, J. P. Martínez, P. Laguna and J. Ramírez

IEEE Transactions on Biomedical Engineering (In Press), doi: 10.1109/TBME.2022.3153791.

The power of genetically diverse individuals in genome-wide association studies of blood lipid levels

S.E. Graham, S.L. Clarke, K.H.Wu, (…), J. Ramírez, (…), P. Deloukas, Y.V. Sun and C.J. Willer

Nature 600, 675-679

Genomic and pleiotropic analyses of resting QT interval identifies novel loci and overlap with atrial electrical disorders

S. van Duijvenboden*, J. Ramírez*, W. Young, M. Orini, B. Mifsud, A. Tinker, P. Lambiase, P. B. Munroe

Human Molecular Genetics, ddab197

Analysing electrocardiographic traits and predicting cardiac risk in UK Biobank

J. Ramírez, S. van Duijvenboden, W.J. Young, M. Orini, A. Jones, P. Lambiase, P. Munroe, A. Tinker

JRSM Cardiovascular Disease, January 2021

ECG-based Monitoring of Blood Potassium Concentration: Periodic versus Principal Component as Lead Transformation for Biomarker Robustness

F. Palmieri, P. Gomis, D. Ferreira, A. Martín-Yebra, Esther Pueyo, J. P. Martínez, J. Ramírez, P. Laguna

Biomedical Signal Processing and Control 2021, 68: 102719

A novel two-stage heart arrhythmia ensemble classifier

M.J. Rezaei, J.R. Woodward, J. Ramírez, P.B. Munroe

Computers 2021, 10(5), 60

Genetically-Determined Serum Calcium levels and Markers of Ventricular Repolarisation: A Mendelian Randomization Study in the UK Biobank

WJ Young, HR Warren, DO Mook-Kanamori, J Ramírez, S van Duijvenboden, M Orini, A Tinker, D van Heemst, PD Lambiase, JW Jukema, PB Munroe, R Noordam

Circulation Genomics and Precision Medicine 2021; 14(3):e003231

Nonlinear T-wave Time Warping-based Sensing Model for Non-invasive Personalized Blood Potassium Monitoring in Hemodialysis Patients

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, J.P. Martínez, J. Ramírez, P. Laguna

Sensors 2021, 21(8), 2710.

Monitoring Blood Potassium Concentration in Hemodialysis Patients by Quantifying T-wave Morphology Dynamics

F. Palmieri, P. Gomis, J. Ruiz, B. Bergasa, D. Ferreira, A. Martín-Yebra, H. Ahmed, J. P. Martínez, E. Pueyo, J. Ramírez, P. Laguna

Scientific Reports 11, 3883.

No Clinically Relevant Effect of Heart Rate Increase and Heart Rate Recovery During Exercise on Cardiovascular Disease: a Mendelian Randomization Analysis

J. Mensah-Kane, A. F. Schmidt, A. D. Hingorani, C. Finan, Y. Chen, S. van Duijvenboden, M. Orini, P. D. Lambiase, A. Tinker, E. Marouli, P. B. Munroe* and J. Ramírez*

Frontiers in Genetics 12(59)

Characterization of T wave Amplitude, Duration and Morphology Changes During Hemodialysis: Relationship with Serum Electrolyte Levels and Heart Rate

H. Ahmed, F. Palmieri, J. Ramírez, P. Laguna, J. Ruiz, D. Ferreira, M. Potse, C. Sanchez-Tapia, E. Pueyo

IEEE Transactions on Biomedical Engineering 68(8), 2467-2478

A method to minimise the impact of ECG marker inaccuracies on the spatial QRS-T angle: Evaluation on 1,512 manually annotated ECGs

W. J. Young, S. van Duijvenboden, J. Ramírez, A. Jones, A. Tinker, P. B. Munroe, P. D. Lambiase, M. Orini

Biomedical Signal Processing and Control 64, 102305

The effects of polygenic risk for psychiatric disorders and smoking behavior on psychotic experiences in UK Biobank

J. García-González, J. Ramírez, D. M. Howard, C. H. Brennan, P. B. Munroe, R. Keers

Translational Psychiatry 2020; 10(330)

Contribution: Supervision and editing the manuscript.

Genetic determinants of electrocardiographic P-wave duration and relation to atrial fibrillation

L. C. Weng, A. Hall, S. H. Choi, (…), J. Ramírez, (…), K. Lunetta, P. Ellinor, and S. Lubitz.

Circulation: Genomic and Precision Medicine 2020; 13:387-395

Contribution: Individual study analyst and data contributor for the meta-analysis.

Genetic Basis and Prognostic Value of Exercise QT Dynamics

S. van Duijvenboden*, J. Ramírez*, W. J. Young, B. Mifsud, M. Orini, A. Tinker, P. B. Munroe and P. D. Lambiase

Circulation: Genomic and Precision Medicine 2020; 13(4)

Contribution: Second leading author, data analysis, manuscript drafting and editing.

Common Genetic Variants Modulate the Electrocardiographic T-peak-to-end Interval

J. Ramírez*, S. van Duijvenboden*, W. J. Young, M. Orini, P. Lambiase, P. B. Munroe, A. Tinker

American Journal of Human Genetics 2020; 106(6):764-778

Contribution: First leading author, data analysis, manuscript drafting and editing.

Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction

Ntalla, L. C. Weng, J. Cartwright, (…), J. Ramírez, (…), Y. Jamshidi , S. Lubitz and P. B. Munroe

Nature Communications 2020; 11(1):1-12

Contribution: Individual study analyst and data contributor for the meta-analysis.

Cardiovascular predictive value and genetic basis of ventricular repolarization dynamics

J. Ramírez, S. van Duijvenboden, N. Aung, P. Laguna, E. Pueyo, A. Tinker, P. D. Lambiase, M. Orini and P.B. Munroe

Circulation: Arrhythmia and Electrophysiology 2019; 12:e007549

Contribution: Leading author, data analysis, manuscript drafting and editing.

Genome-wide association study identifies loci for arterial stiffness index in 127,121 UK Biobank participants

K. Fung, J. Ramírez, H. R. Warren, N. Aung, A. M. Lee, E. Tzanis, S. E. Petersen and P. B. Munroe

Scientific Reports 2019; 9:9143

Contribution: Supervision and editing the manuscript.

The effects of polygenic risk for psychiatric disorders and smoking behavior on psychotic experiences in UK Biobank

J. García-González, J. Ramírez, D. M. Howard, C. H. Brennan, P. B. Munroe, R. Keers

Translational Psychiatry 2020; 10(330)

Contribution: Supervision and editing the manuscript.

Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6

B. P. Prins, T. J. Mead, J. A. Brody, (…), J. Ramirez, (…), P. B Munroe, D. E Arking, C. W Lo, Y. Jamshidi

Genome Biology 2018; 19(1):87

Contribution: Individual study analyst and data contributor for the meta-analysis.

Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

J. Ramírez*, S. van Duijvenboden*, I. Ntalla*, B. Mifsud, H. R. Warren, E. Tzanis, M. Orini, A. Tinker, P. D. Lambiase and P. B. Munroe

Nature Communications 2018; 9(1):1947

Contribution: First leading author, data analysis, manuscript drafting and editing.

Sudden cardiac death and pump failure death prediction in chronic heart failure by combining ECG and clinical markers in an integrated risk model

J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayes de Luna, J. P. Martinez, P Laguna and E. Pueyo

PLoS ONE 2017; 12(10):e0186152.

Contribution: Leading author, data analysis, manuscript drafting and editing.

T-wave Morphology Restitution Predicts Sudden Cardiac Death in Patients with Chronic Heart Failure

J. Ramírez, M. Orini, A. Mincholé, V. Monasterio, I. Cygankiewicz, A. Bayes de Luna, J. P. Martinez, E. Pueyo and P. Laguna

JAHA 2017; 6(5):e005310.

Variability of ventricular repolarization dispersion quantified by time-warping the morphology of the T-waves

J. Ramírez, M. Orini, J. D. Tucker, Esther Pueyo and Pablo Laguna.

IEEE Trans on Biomed Eng, 64(7), pp. 1619-1630.

Contribution: First leading author, data analysis, manuscript drafting and editing.

Automatic SVM classification of sudden cardiac death and pump failure death from autonomic and repolarization ECG markers

J. Ramírez, V. Monasterio, A. Mincholé, M. Llamedo, G. Lenis, I Cygankiewicz, A. Bayes de Luna, M. Malik, J. P. Martinez, P Laguna and E. Pueyo

J Electrocardiol 48, pp. 551-557.

Contribution: First leading author, data analysis, manuscript drafting and editing.

QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure: Relation to sudden cardiac death

J. Ramírez, P. Laguna, A. Bayés de Luna, M. Malik and E. Pueyo

J Electrocardiol 47, pp. 842-848.

Contribution: First leading author, data analysis, manuscript drafting and editing.

Classifying Left Ventricular Hypertrophy from Extracted Morphological Electrocardiogram Biomarkers using Random Forest

Hafiz Naderi, Julia Ramírez, Stefan van Duijvenboden, Esmeralda Ruiz Pujadas, Lin Wang, Karim Lekadir, Steffen E Petersen, Patricia B Munroe

CINC 2022

Combination of Isolation Forest, SMOTE and Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia

Mercedeh J. Rezaei; John R. Woodward; Julia Ramirez; Patricia Munroe

International Conference on Biomedical Innovations and Applications.

Ensemble Learning for the classification of Atrial Fibrillation and Ventricular Arrhythmia

M. J. Rezaei, J. Woodward, J. Ramírez, P.B. Munroe.

International Conference on Biomedical Innovations and Applications.

Weighted Time Warping T-wave Analysis Robust to Delineation Errors: Clinical Implications

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez

Computing in Cardiology. Brno (Czech Republic)

«Time-Warping» ponderado sobre la onda T para Reducir el Impacto de Errores de Delineación: Implicaciones Clínicas

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, E. Pueyo, J.P. Martínez, P. Laguna, J. Ramírez

Congreso Annual de la Sociedad Española de Ingeniería Biomédica.

Evaluating the Impact of Physiological Variability in Genome-Wide Association Studies of Resting Heart Rate

S. van Duijvenboden, J. Ramírez, W.J. Young, A. Tinker, P.B. Munroe, P.D. Lambiase, M. Orini

Computing in Cardiology. Rimini (Italy)

Will Genetic Data Significantly Change Cardiovascular Risk Prediction in Daily Practice?

W.J. Young, J. Ramírez, S. van Duijvenboden, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini

Computing in Cardiology. Rimini (Italy)

Potassium Monitoring From Multilead T-wave Morphology Changes During Hemodyalisis: Periodic Versus Principal Component Analysis

F. Palmieri, P. Gomis, J.E. Ruiz, D. Ferreira, A. Martín-Yebra, E. Pueyo, P. Laguna, J.P. Martínez, J. Ramírez

Computing in Cardiology. Rimini (Italy)

Sex Differences in the Morphology of RR-Matched T-waves

J. Ramírez, S. van Duijvenboden, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini

Computing in Cardiology. Rimini (Italy)

Interaction Between ECG and Genetic Markers of Coronary Artery Disease

J. Ramírez, S. van Duijvenboden, W.J. Young, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini

Computing in Cardiology. Rimini (Italy)

Genetic Architecture of Quantitative Cardiovascular Traits: Blood Pressure, ECG and Imaging Phenotypes

N. Aung, W.J. Young, S. van Duijvenboden, J. Ramírez, S.E. Petersen, P.B. Munroe

Computing in Cardiology. Rimini (Italy)

Data augmentation for heart arrhythmia classification

M. Jafarkhanloo Rezaei, J. Woodward, J. Ramírez, P. B. Munroe

IEEE International Conference on Tools with Artificial Intelligence (ICTAI)

Monitorización en diálisis de la Concentración de Potasio en Sangre mediante los cambios en la morfología multi-lead de la onda T: Comparación Entre usar la transformación en Componentes Periódicas y Principales

Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Dina Ferreira, Alba Martin, Esther Pueyo, Pablo Laguna, Juan Pablo Martínez and Julia Ramírez

XL Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Bilbao, Spain

Transmural Ventricular Heterogeneities Play a Major Role in Determining T-Wave Morphology at Different Serum Potassium Levels

Syed Hassaan Ahmed Bukhari, Flavio Palmieri, Dina Ferreira, Mark Potse, Julia Ramírez, Pablo Laguna, Carlos Sanchez and Esther Pueyo

Computing in Cardiology. Singapore, Singapore

T-Wave Morphology Changes as Surrogate for Blood Potassium Concentration in Hemodialysis Patients

Flavio Palmieri, Pedro Gomis, José Esteban Ruiz, Beatriz Bergasa, Ferreira Dina, Alba Martin, Syed Hassaan Ahamed, Esther Pueyo, Juan Pablo Martínez, Julia Ramírez and Pablo Laguna

Computing in Cardiology. Singapore, Singapore

Winner of the “ESC-CinC Clinical Needs Translational Award”

Assessing a Warping Methodology for the Identification of Increased Cardiovascular Risk Based on the HR Profile Morphology

J. Ramírez, S. van Duijvenboden, P. Laguna, E. Pueyo, A. Tinker, P.D. Lambiase, P.B. Munroe, M. Orini.

Computing in Cardiology. Maastrich, The Netherlands.

Winner of the “ESC-CinC Clinical Needs Translational Award”.

T-wave Morphology Restitution in Chronic Heart Failure Patients with Atrial Fibrillation,

F. Palmieri, J.P. Martínez, L. Burattini, J. Ramírez.

Computing in Cardiology. Maastrich, The Netherlands.

Comparison of ECG T-wave Duration and Morphology Restitution Markers for Sudden Cardiac Death Prediction in Chronic Heart Failure

J. Ramirez, M. Orini, E. Pueyo, P. Laguna.

Computing in Cardiology. Rennes, France.

T-wave Morphology Restitution Dependency with Heart Rate Range and Its Association with Sudden Cardiac Death in Chronic Heart Failure

J. Ramirez, M. Orini, E. Pueyo, P. Laguna.

Computing in Cardiology. Rennes, France.

Quantification of T-wave Morphological Variability Using Time-Warping Methods,

J. Ramirez, M. Orini, E. Pueyo, P. Laguna.

European Medical and Biological Engineering and Nordic-Baltic Biomedical Engineering conference. Tampere, Finland.

Cuantificación de la variabilidad de la amplitud de la onda T mediante técnicas de re-parametrización temporal

J. Ramírez, M. Orini, J.D. Tucker, et.al.,

XXXIV Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Valencia, Spain.

An index for T-wave pointwise amplitude variability quantification.

J. Ramírez, M. Orini, J. D. Tucker, Esther Pueyo and Pablo Laguna.

Computing in Cardiology. Vancouver, Canada,

Winner of the “Mortara” mobility fellowship.

Post extrasystolic T wave change to stratify risk of pump failure death in patients with chronic heart failure.

G. Lenis, R. Menges, J. Ramírez, I. Cygankiewicz, A. Bayés de Luna, J.P. Martínez, P. Laguna, O. Dossel,

Computing in Cardiology. Vancouver, Canada, 2016,

Winner of the “Mortara” mobility fellowship.

Modulación circadiana y de género de las relaciones QT/RR y T-pico-a-fin/RR en pacientes con insuficiencia cardiaca

J. Ramírez, P. Laguna y E. Pueyo ,

XXXII Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). Barcelona, Spain.

Circadian pattern and sex differences of QT/RR and T-peak-to-end/RR curvatures and slopes in chronic heart failure patients

J. Ramírez, I. Cygankiewicz, P. Laguna, M. Malik, E. Pueyo,

Computing in Cardiology, Cambridge, MA, United States of America.

Prediction of sudden cardiac death in chronic heart failure patients by analysis of restitution dispersion

J. Ramírez, A. Mincholé, J. Bolea, P. Laguna, E. Pueyo,

Computing in Cardiology. Zaragoza, Spain,

Winner of the Young Investigator Award for the best written and oral presentation.

Caracterización de la respuesta de la repolarización a cambios en el ritmo cardiaco provocados por una prueba de Tilt

J. Ramírez, A. Mincholé, P. laguna, et al,

XXX Congreso Anual de la Sociedad Española de Ingeniería Biomédica (CASEIB). San Sebastián, Spain.

Characterization of cardiac repolarization response to heart rate changes provoked by a Tilt test

J. Ramírez, A. Mincholé, P. Laguna, E. Pueyo

Computing in Cardiology. Krakow, Poland,

Winner of the “Bill and Sanders Award” for the best poster presentation.